When George Prendergast, PhD, was hired as President and CEO of the Lankenau Institute for Medical Research (LIMR) in 2004, he set out on the biggest experiment of his life: going against nonprofit research norms by seeking to link academic pursuits to a culture of invention. He even coined a term for the approach—acapreneurial™—to represent this academic/entrepreneurial hybrid.
The fruits of the journey are evident today. LIMR is patenting experimental tests and treatments at an increasing rate for cancer, diabetes, infectious diseases and other medical conditions, in addition to patenting clinical devices aimed at improving care in the hospital setting. Meanwhile, its scientists are also publishing more academic research papers than at any point in the Institute's history.
Before Dr. Prendergast arrived, LIMR conducted biomedical research adhering to the traditional academic model followed by virtually every other nonprofit institution: seeking knowledge to advance medical science regardless of whether it might deliver tangible benefits to patients in the foreseeable future.
That approach, however, represented a disconnect.
- Those in the philanthropic world are motivated by the promise of new knowledge that can be converted into useful inventions and treatments in a reasonable amount of time to improve human health and wellbeing.
- Academic scientists themselves find that without patent protection, their new knowledge and concepts are often difficult to advance to creating practical societal impact.
With the support of the LIMR Board and Main Line Health, Dr. Prendergast began to infuse the ACAPRENEURIALTM culture into the Institute to try to grow its effectiveness and impact.
The model focuses on invention, intellectual property and new company development, with a secondary goal of the traditional academic pursuit of new knowledge and its validation.
The results have been to transform LIMR into an organization that has increased in productivity relative to its peers without significant changes in the overall support for its budget from its main funders: the Lankenau Medical Center Foundation and the Main Line Health system.
Meeting the 'bench to bedside' challenge
The "bench to bedside" concept refers to moving discoveries from the laboratory into use in the hospital setting. Acapreneurialism targets that goal directly by focusing on inventions that can be moved swiftly into use to improve patient care. In essence, acapreneurialism recognizes that "bench to bedside moves through biotech."
What does it mean to move through the biotechnology and pharmaceutical industries, and why is it necessary? New drug and test discovery entail years of preclinical and clinical testing and the involvement of thousands of patients before applying for FDA approval to go to market. Hundreds of millions of dollars are required to navigate this path, and it is fraught with complex regulatory issues, making corporate investment indispensable. That's where patents come into play. Licensing inventions that have been patented — meaning the intellectual property is protected — is generally viewed by potential funders as a prerequisite before they will consider investment.
LIMR's hybrid design is better at meeting this challenge. In fact, LIMR is a hybrid not only in its culture but its physical existence. In one facility, it fuses academic, entrepreneurial, clinical and population health elements that typically exist separately in academic and for-profit institutions.
LIMR also serves as a business incubator. Biotechnology start-up companies are literally located side by side with the laboratories of researchers and those performing clinical research. The mixture is a powerful engine for new knowledge and product development.
Acapreneurialism by the numbers
- 40+: U.S. and international patents
- 25+: Technologies and products licensed
- 10+: Companies spun off or incubated, including Immunome going public
The success stories of acapreneurialism have grown substantially:
Learn about the successes of companies that have incubated and spun off as a result of LIMR’s ACAPRENEURIALTM approach.
- Acquires rights to one of Institute's antimetabolite drug technologies for cancer treatment (2015)
- LIMR's first minority-owned licensee
- Key supporters include Ben Franklin Technology Partners and the Frederick National Cancer Laboratory, a division of the National Cancer Institute
- Collaborates with LIMR faculty members in co-inventing a set of experimental therapies based on the company's 3DNA nanoparticle technology (2012)
- Acquired by Code Biotherapeutics, which continues to advance these co-inventions' development with LIMR (2021)
- Started by Lankenau orthopedic surgeon Carl Deirmengian, MD, to develop his point-of-care infection detection device used during joint replacement surgery (2010)
- Acquired by Zimmer Bionet (2016)
- Company's paradigm-shifting product, Synovasure®, receives FDA approval (2019)
- LIMR's first fully owned spin-out (2007)
- Licenses the Institute's IDO2 gene, antibody and drug technology for commercial development (2007)
- Acquired by NewLink Genetics (2009)
- LIMR's first all-female-led and first "spin-in" company
- Advances development of diabetes treatment technology pioneered by Lankenau endocrinologist Claresa Levatan, MD, et al. in cooperation with LIMR's Lisa Laury-Kleintop, PhD (2006)
- Acquired by Boston Therapeutics Inc. (2018), which merges with Nanomix Inc. (2021)
- Conducts research at LIMR, opening clinical trials that include Main Line Health (2005-2011)
- Acquires LIMR Development Inc. (2009)
- Acquired by Lumos Pharma (2020)
- First company incubated at LIMR (2003)
- Licenses Institute's IDO drug technology for cancer immunotherapy (2003)
- Acquired by NewLink (2005)
The 4 pillars of acapreneurialism
To achieve its goals, LIMR has aligned its activities to a structure now demonstrated to be successful. It has four pillars: patent-based philosophy, hybrid management style, co-invention, and trading space and services for equity.
LIMR biomedical researchers must invent and then seek to patent and license their inventions to a company for development. To get there requires following what Dr. Prendergast calls the "three Ps of innovation"—preclinical proof of concept, patent application and peer-reviewed publication. In other words, LIMR has reoriented itself from the traditional approach focused on grant funding to pursue new biomedical knowledge to one that focuses on investments in new inventions and patent licenses.
Hybrid management style
LIMR navigates a path between two traditional approaches: the independence of the tenured academic investigator versus the top-down direction of the corporate researcher. LIMR regularly holds internal meetings to dynamically shift management based on the practical application of the research, building mutual trust among faculty and other program leaders in the institutional mission to invent and advance experimental products from new knowledge and discoveries.
Faculty are encouraged to participate as advisers or science officers in start-up companies, within the guidelines of patent and start-up policies approved by the LIMR and Main Line Health Boards. New mechanisms of financial support are enabled by such relationships to help speed lab-based discoveries to clinical testing.
Trading space and services for equity
The incubation model includes the trading of institutional space and services for equity positions in companies ("spin-ins") that advance LIMR's mission. For the most attractive inventions made by Main Line Health physicians and LIMR scientists, the Institute has also made capital investments from its endowment holdings. This pillar seeks financial return on the success of the Institute's inventors to enable future financial sustainability for making new discoveries.
The next phase: clinical acapreneurialism
In 2019, Dr. Prendergast saw that medical devices and software represented an untapped pathway for invention—and that frontline healthcare workers were the natural source of ideas to directly benefit patients. LIMR retained L2C Partners of Wynnewood, Pennsylvania, to manage its burgeoning portfolio of intellectual property to support technology transfer and commercialization—the types of expertise needed to pursue the new direction.
Then, in 2021, Lankenau Ventures was created to accelerate the development and commercialization of clinical devices invented by Main Line Health nurses and other healthcare professionals for use in various hospital settings, such as patient and operating rooms. It is a joint venture of LIMR, L2C Partners, and Early Charm Ventures of Baltimore, which specializes in bringing such devices to market.